Nine straight. Now prove it again.

Arizona starts by feeding Trey McBride.

Who owns the middle of the field, especially with Nick Emmanwori still limited in practice.

McBride caught nine passes for 95 yards and a touchdown in Week 1. Brissett wants a dependable answer inside, and Seattle's safety health changes how aggressively the defense can rotate coverage toward him.

Brissett keeps getting the ball out before pressure arrives.

Whether Seattle changes his first read instead of only trying to win faster up front.

Arizona's Week 1 offense lived in rhythm. Seattle's simulated-pressure game works best when the protection and quarterback identify different threats before the snap.

Arizona's guards start shuffling bodies.

Leonard Williams and Byron Murphy inside, especially on third-and-medium.

Left guard Isaac Seumalo is dealing with a shoulder injury and right guard Isaiah Adams is working back from a knee injury. Both were limited Thursday. That is the cleanest injury-to-matchup connection on Arizona's side.

Seattle goes three-and-out early.

The total snap count and Arizona's possession time, not only the score.

Seattle ran only 48 plays in Week 1. Arizona ran 72 and held the ball for 37:31. Seattle does not want its defense absorbing another 65 to 70 snaps.

Lock gets an early first-down play-action throw.

Whether JSN is the first read and whether Arizona's linebackers step toward the run fake.

Lock was efficient in relief, and Seattle's biggest offensive play in Week 1 was his 45-yard touchdown to JSN from a run-action look on fourth-and-1.

Seattle keeps handing it off into a crowded front.

Whether the run is earning another carry or only setting up the next throw.

Seattle's Week 1 rush efficiency was poor even though Jadarian Price averaged 5.2 yards per carry. Arizona's defense also held the Chargers to 81 rushing yards.

JSN starts winning immediately.

How quickly Arizona rolls help toward him and who becomes Seattle's second answer.

JSN opened the year with eight catches for 122 yards and the touchdown. Cooper Kupp upgraded to full participation Thursday, while Tory Horton has practiced in full both days.

Arizona keeps reaching second-and-short.

Whether Seattle is losing to quick throws or giving up efficient runs.

Arizona's opener worked because it stayed on schedule. Seattle's best response is forcing Brissett into obvious passing downs where the disguise package has more value.

The game is still within one score in the fourth quarter.

Turnover margin before anything else.

Seattle won Week 1 with zero giveaways and three takeaways. Arizona also played turnover-free football while taking the ball away twice. Both teams just won with the clean version of the same formula.

Arizona hangs around despite losing the efficiency battle.

Special teams and short fields.

Arizona blocked a punt in Week 1 and turned it into a touchdown from the Chargers' 3-yard line. In a low-scoring divisional game, one short field changes the script.